The Blood-Brain Barrier (BBB)

The Blood-Brain Barrier (BBB)

Our laboratories utilize both in vitro and in vivo models of the human blood-brain barrier to investigate the ability of various agents to cross the BBB as well as to examine the effect of agents on the integrity of the BBB. Our in vitro models consist of a high-throughput 2 dimensional system that can rapidly investigate the ability of agents to cross it and affect its integrity. A 3 dimensional model more closely mimics the physiological human BBB and allows for more detailed studies of the BBB. Furthermore we can assess the ability of compounds to cross the BBB in vivo using small animal (rats and mice) models.

 

Applications

Our BBB models can determine the efficiency of a wide range of compounds to cross the BBB and concurrently determine their effects on the integrity of the BBB. Using a wide range of nanoparticles that we have developed, we can facilitate the transfer of molecules (e.g. drugs, nucleic acids, proteins, etc.) that normally do not penetrate the central nervous system using a wide range of nanoparticles that we have previously synthesized. Custom synthesis of targeted nanoparticles for the enhanced delivery of agents across the BBB is available. A variant of the BBB is blood-nerve barrier (BNB) which can inhibit the delivery of drugs to peripheral nerves for the therapy of peripheral neuropathies. We have formulated nanoparticles that have a high efficiency in the crossing the BNB and may be useful for the therapy of wide range of degenerative neuropathies.

 

  • Custom synthesis of nanoparticles that efficiently pass the BBB and/or the BNB.
  • Complexing of wide range of therapeutic agents to nanoparticles for their transfer across the BBB and/or BNB.
  • Complexing of ligands to therapeutic nanoparticles to further enhance their ability to cross the BBB and to target specific cells in the CNS.